• Intervention
    What is the relationship between supplemental coenzyme Q10 and cardiovascular disease?
    • Conclusion

      Not enough evidence exists to demonstrate the benefits or harm of supplemental Coenzyme Q10 and its use in CVD.

    • Grade: III
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
    For the patient with heart failure, does CoEnzyme Q10 provides beneficial outcomes?
    • Conclusion

      The majority of evidence available indicates that patients with heart failure may benefit from using CoEnzyme Q10. Six studies reported a benefit of using CoQ10. Five of these were of neutral quality and four contained small sample sizes. A larger systematic review, which included five placebo controlled, randomized design studies along with a meta-analysis, found four studies with positive outcomes with supplementation of CoQ10 in patients with HF. Outcomes from three of these four studies included a statistically significant increase in exercise tolerance and quality of life with a decrease in symptomolgy. One study (with a small sample size; n=46) found no benefit from CoQ10 in patients with heart failure. 

    • Grade: II
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.
  • Basic Research
    What is the relationship between HMG-CoA reductase inhibitors and coenzyme Q10?
    • Conclusion

      HMG-CoA reductase inhibitors (a cholesterol lowering class of medicines, also called statins) have been shown to decrease plasma levels of coenzyme Q10. Levels can be normalized when coenzyme Q10 supplementation is taken at the same time as the statin drugs however the clinical significance of this has not been determined.

    • Grade: IV
      • Grade I means there is Good/Strong evidence supporting the statement;
      • Grade II is Fair;
      • Grade III is Limited/Weak;
      • Grade IV is Expert Opinion Only;
      • Grade V is Not Assignable.
      • High (A) means we are very confident that the true effect lies close to that of the estimate of the effect;
      • Moderate (B) means we are moderately confident in the effect estimate;
      • Low (C) means our confidence in the effect estimate is limited;
      • Very Low (D) means we have very little confidence in the effect estimate.
      • Ungraded means a grade is not assignable.