• In adults, does using foods or beverages with aspartame in a calorie-restricted or ad libitum diet affect energy balance (weight)?
• In children, does using beverages with aspartame in a calorie-restricted or ad libitum diet affect energy balance (weight)?

• In adults, does using foods or beverages with aspartame affect appetite or food intake?
• In children, does using foods or beverages with aspartame affect appetite or food intake?

Aspartame and Preference for Sweetness

• Does aspartame affect preference for sweetness?

• What is the evidence from human subjects research that aspartame consumption is associated with adverse effects in the general population?
• What is the evidence from human subjects research that aspartame consumption is associated with adverse effects in special populations including children?

High Fructose Corn Syrup (HFCS)

• What is the evidence from human subject research that consumption of high fructose corn syrup is associated with obesity, metabolic and/or adverse effects in adults?

• In adults, does using foods or beverages with neotame in a calorie-restricted or ad libitum diet affect energy balance?

• In children, does using beverages with neotame in a calorie-restricted or ad libitum diet affect energy balance(weight)?

• In adults, does using foods or beverages with neotame affect appetite?
• In children, does using foods or beverages with neotame affect appetite?
• In adults, does neotame affect food intake?

• In children, does neotame affect food intake?

• Do intakes of neotame and the foods and beverages to which it is added, assist consumers in meeting recommended dietary goals?

• Do intakes of neotame affect energy density?

• What is the estimated neotame consumption level and is it within acceptable daily intake (ADI) limits?

• Can neotame be used to manage diabetes and glycemic response?
• What is the intake of neotame in persons with diabetes, and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?

• Can neotame be used to prevent and manage hyperlipidemias?

• Does neotame affect behavior changes, cognitive function or moods?

• What is the evidence from human subjects research that neotame consumption is associated with adverse effects in the general population?

• What is the evidence from human subject research that consumption of polyols/sugar alcohols is associated with metabolic and/or adverse effects in adults?

• In adults, does using foods or beverages with saccharin affect appetite?
• In adults, does saccharin affect food intake in adults?
• In children, does saccharin affect food intake?
• In children, does using foods or beverages with saccharin affect appetite?

• In adults, does using foods or beverages with saccharin in a calorie-restricted or ad libitum diet affect energy balance?
• In children, does using beverages with saccharin in a calorie-restricted or ad libitum diet affect energy balance (weight)?

• Do intakes of saccharin affect energy density?

• What is the estimated saccharin consumption level and is it within acceptable daily intake limits?

• Do intakes of saccharin and the foods and beverages to which it is added, assist adult consumers in meeting recommended dietary goals?
• Do intakes of saccharin and the foods and beverages to which it is added, assist child consumers in meeting recommended dietary goals?

• Does saccharin affect behavior changes, cognitive function or moods?

• In adults, can saccharin be used to manage diabetes and glycemic response?
• In children, can saccharin be used to manage diabetes and glycemic response?
• In children with diabetes, what is the intake of saccharin, and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
• In adults with diabetes, what is the intake of saccharin and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?

• In adults, can saccharin be used to prevent and manage hyperlipidemias?
• In children, can saccharin be used to prevent and manage hyperlipidemias?

• What is the evidence from human subjects research that saccharin consumption is associated with adverse effects in the general population?

• In adults, is there evidence regarding the influence of stevia on metabolic outcomes and/or weight?
• In adults, is there evidence regarding the influence of stevia on metabolic outcomes and/or weight?

• In adults, does using foods or beverages with sucralose in a calorie-restricted or ad libitum diet affect energy balance?
• In children, does using beverages with sucralose in a calorie-restricted or ad libitum diet affect energy balance (weight)?

• In adults, does sucralose affect food intake?
• In children, does sucralose affect food intake?
• In adults, does using foods or beverages with sucralose affect appetite?
• In children, does using foods or beverages with sucralose affect appetite?

• Do intakes of sucralose, and the foods and beverages to which it is added, assist consumers in meeting recommended dietary goals?

• Do intakes of sucralose affect energy density?

• What is the estimated sucralose consumption level and is it within acceptable daily intake (ADI) limits?

• In adults, can sucralose be used to manage diabetes and glycemic response?
• What is the intake of sucralose in persons with diabetes and is this within the Acceptable Daily Intake (ADI) of non-nutritive sweeteners?
• In children, can sucralose be used to manage diabetes and glycemic response?

• Does sucralose affect behavior changes, cognitive function or moods?

• In adults, can sucralose be used to prevent and manage hyperlipidemias?
• In children, can sucralose be used to prevent and manage hyperlipidemias?

• What is the evidence from human subjects research that sucralose consumption is associated with adverse effects in the general population?

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